Mol Cell. 2008 Jul 11;31(1):2-4. doi: 10.1016/j.molcel.2008.06.012.

Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics.

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Department of MCD Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. hartzog@biology.ucsc.edu

Abstract

In this issue of Molecular Cell, Fleming et al. (2008) show that histone H2B ubiquitylation and FACT function interdependently to facilitate nucleosome reassembly during transcription elongation, thereby demonstrating that histone posttranslational modifications can provide important but transient transcriptional signaling cues.

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H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. [Mol Cell. 2008]
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation.Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA. Mol Cell. 2008 Jul 11; 31(1):57-66.

PMID:: 18614040; [PubMed - indexed for MEDLINE]

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H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. [Mol Cell. 2008]
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation.
Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA. Mol Cell. 2008 Jul 11; 31(1):57-66.
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. [J Biol Chem. 2002]
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
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Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. [Proc Natl Acad Sci U S A. 2009]
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Cited by 3 PubMed Central articles

Genome-wide function of H2B ubiquitylation in promoter and genic regions. [Genes Dev. 2011]
Genome-wide function of H2B ubiquitylation in promoter and genic regions.
Batta K, Zhang Z, Yen K, Goffman DB, Pugh BF. Genes Dev. 2011 Nov 1; 25(21):2254-65.
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Elongin B-mediated epigenetic alteration of viral chromatin correlates with efficient human cytomegalovirus gene expression and replication.
Hwang J, Saffert RT, Kalejta RF. MBio. 2011; 2(2):e00023-11. Epub 2011 Mar 29.
Review Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. [Epigenetics. 2010]
Review Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation.
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Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics.
Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics.
Mol Cell. 2008 Jul 11 ;31(1):2-4. doi: 10.1016/j.molcel.2008.06.012.

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