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Mol Cell. 2008 Jul 11;31(1):2-4. doi: 10.1016/j.molcel.2008.06.012.

Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics.

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  • 1Department of MCD Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. hartzog@biology.ucsc.edu


In this issue of Molecular Cell, Fleming et al. (2008) show that histone H2B ubiquitylation and FACT function interdependently to facilitate nucleosome reassembly during transcription elongation, thereby demonstrating that histone posttranslational modifications can provide important but transient transcriptional signaling cues.

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