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Cell. 2008 Jul 11;134(1):16-8. doi: 10.1016/j.cell.2008.06.031.

Clearing the way for unpaused polymerases.

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  • 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.


Heat shock loci in the polytene chromosomes of the fruit fly Drosophila undergo a characteristic change in appearance that coincides with the onset of gene expression. Petesch and Lis (2008) now show that nucleosomes are lost across the entire Hsp70 locus in an initial wave that precedes transcription by RNA polymerase II.

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