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Cell. 2008 Jul 11;134(1):14-6. doi: 10.1016/j.cell.2008.06.041.

Interchromosomal huddle kickstarts antiviral defense.

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  • 1The Babraham Institute, Laboratory of Chromatin and Gene Expression, Babraham Research Campus, Cambridge, UK.


Long-distance chromosomal interactions are emerging as a potential mechanism of gene expression control. In this issue, Apostolou and Thanos (2008) describe how viral infection elicits interchromosomal associations between the interferon-beta (IFN-beta) gene enhancer and DNA binding sites of the transcription factor NF-kappaB, resulting in the initiation of transcription and an antiviral response.

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