J Infect Dis. 2008 Aug 15;198(4):571-5.

Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice.

Arrecubieta C, Matsunaga I, Asai T, Naka Y, Deng MC, Lowy FD.

Source

Divisions of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

Abstract

Staphylococcus aureus is a leading cause of ventricular assist device-related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection.

PMID:: 18613794; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Staphylococcal Infections - MedlinePlus Health Information

Supplemental Content

Related citations

Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant. [J Infect Dis. 2001]
Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant.
Josefsson E, Hartford O, O'Brien L, Patti JM, Foster T. J Infect Dis. 2001 Dec 15; 184(12):1572-80. Epub 2001 Dec 3.
Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis. [J Exp Med. 2005]
Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis.
Que YA, Haefliger JA, Piroth L, François P, Widmer E, Entenza JM, Sinha B, Herrmann M, Francioli P, Vaudaux P, et al. J Exp Med. 2005 May 16; 201(10):1627-35.
Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model. [Infect Immun. 2006]
Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model.
Schaffer AC, Solinga RM, Cocchiaro J, Portoles M, Kiser KB, Risley A, Randall SM, Valtulina V, Speziale P, Walsh E, et al. Infect Immun. 2006 Apr; 74(4):2145-53.
Review Extracellular-matrix-binding proteins as targets for the prevention of Staphylococcus aureus infections. [Mol Med Today. 1999]
Review Extracellular-matrix-binding proteins as targets for the prevention of Staphylococcus aureus infections.
Flock JI. Mol Med Today. 1999 Dec; 5(12):532-7.
Review A humanized monoclonal antibody targeting Staphylococcus aureus. [Vaccine. 2004]
Review A humanized monoclonal antibody targeting Staphylococcus aureus.
Patti JM. Vaccine. 2004 Dec 6; 22 Suppl 1:S39-43.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Progress in the development of effective vaccines to prevent selected gram-positive bacterial infections. [Am J Med Sci. 2010]
Review Progress in the development of effective vaccines to prevent selected gram-positive bacterial infections.
Bronze MS, Dale JB. Am J Med Sci. 2010 Sep; 340(3):218-25.
Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions. [BMC Microbiol. 2010]
Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions.
McCarthy AJ, Lindsay JA. BMC Microbiol. 2010 Jun 15; 10:173. Epub 2010 Jun 15.
Selection and characterization of murine monoclonal antibodies to Staphylococcus aureus iron-regulated surface determinant B with functional activity in vitro and in vivo. [Clin Vaccine Immunol. 2009]
Selection and characterization of murine monoclonal antibodies to Staphylococcus aureus iron-regulated surface determinant B with functional activity in vitro and in vivo.
Brown M, Kowalski R, Zorman J, Wang XM, Towne V, Zhao Q, Secore S, Finnefrock AC, Ebert T, Pancari G, et al. Clin Vaccine Immunol. 2009 Aug; 16(8):1095-104. Epub 2009 Jun 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Vaccination with clumping factor A and fibronectin binding protein A to prevent ...
Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice.
J Infect Dis. 2008 Aug 15 ;198(4):571-5.

PubMed
Community-acquired methicillin-resistant Staphylococcus aureus in hospitalized a...
Community-acquired methicillin-resistant Staphylococcus aureus in hospitalized adults and children without known risk factors.
Clin Infect Dis. 1999 Oct ;29(4):797-800.

PubMed
Update on emerging infections: news from the Centers for Disease Control and Pre...
Update on emerging infections: news from the Centers for Disease Control and Prevention.
Ann Emerg Med. 2003 Jan ;41(1):148-51.

PubMed
Vaccine assembly from surface proteins of Staphylococcus aureus.
Vaccine assembly from surface proteins of Staphylococcus aureus.
Proc Natl Acad Sci U S A. 2006 Nov 7 ;103(45):16942-7. Epub 2006 Oct 30 .

PubMed
Heterogeneous in vivo expression of clumping factor A and capsular polysaccharid...
Heterogeneous in vivo expression of clumping factor A and capsular polysaccharide by Staphylococcus aureus: implications for vaccine design.
Vaccine. 2009 May 26 ;27(25-26):3276-80. Epub 2009 Feb 5 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information