J Am Acad Orthop Surg. 2008;16 Suppl 1:S56-62.

What other biologic and mechanical factors might contribute to osteolysis?

Greenfield EM, Bechtold J; Implant Wear Symposium 2007 Biologic Work Group.

Collaborators (16)

Bauer TW, Bechtold J, Bostrom M, Campbell PA, Goldberg V, Goodman SB, Greenfield EM, Jacobs JJ, Konttinen Y, O'Keefe R, Lee FY, Schwarz EM, Shanbhag AS, Smith RL, Tuan RS, Wilkinson JM.

Source

Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, USA.

Abstract

An overwhelming consensus exists that wear particles are the primary driving force in aseptic loosening of orthopaedic implants. Nonetheless, considerable evidence has emerged demonstrating that various other factors can modulate the biologic activity of orthopaedic wear particles. Two of the most studied modulating factors are bacterial endotoxins and implant motion.

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