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J Enzyme Inhib Med Chem. 2009 Apr;24(2):457-63. doi: 10.1080/14756360802188628 .

Anti-tubercular activity of ruthenium (II) complexes with polypyridines.

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  • 1Laboratoire Chimie des Materiaux, Faculte des Sciences, Oujda, Morocco.


A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.

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