Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA. kelleymt@nidcd.nih.gov
Wnt signaling regulates many aspects of development through canonical and PCP signaling pathways. A paper by Yamamoto et al. in this issue of Developmental Cell identifies collagen triple helix repeat containing 1 as a Wnt-binding cofactor that specifically activates the Wnt-PCP pathway.