Second hit in cervical carcinogenesis process: inv...[Int Arch Med. 2008]

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1: Int Arch Med. 2008 Jul 7;1(1):10. Links

Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway.

Perez-Plasencia C, Duenas-Gonzalez A, Alatorre-Tavera B.

Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autonóma de Mexico UNAM, Instituto Nacional de Cancerologa INCAN, Mexico City, Mexico. car_plas@yahoo.com.

ABSTRACT: The Human papillomavirus plays an important role in the initiation and progression of cervical cancer. However, it is a necessary but not sufficient cause to develop invasive carcinoma; hence, other factors are required in the pathogenesis of this malignancy. In this review we explore the hypothesis of the deregulation of wnt/beta-catenin signaling pathway as a "second hit" required to develop cervical cancer.

PMID: 18606007 [PubMed - in process]

PMCID: PMC2491599

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