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J Artif Organs. 2008;11(2):100-3. doi: 10.1007/s10047-008-0406-7. Epub 2008 Jul 6.

Clinical trial of allogeneic cultured dermal substitutes for intractable skin ulcers of the lower leg.

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  • 1Department of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Japan. ymprs@med.kitasato-u.ac.jp


The efficacy of allogeneic cultured dermal substitute (CDS) on wound healing was evaluated in six patients with intractable skin ulcers on the lower extremities. Allogeneic CDS was repeatedly applied to wounds at intervals of 4-7 days to prepare a wound bed acceptable for skin grafting or to induce resurfacing through the granulation tissue formation associated with epithelialization. In one patient with a leg ulcer, the wound size decreased to 32% of the original size within 10 weeks and skin grafting was conducted. In the other five patients with leg, ankle, or foot ulcers, the wound size decreased to 9%-25% of the original size within 6 weeks.

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