Trends Immunol. 2008 Aug;29(8):380-7. Epub 2008 Jul 2.

Factor H family proteins and human diseases.

Source

Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena D-07745, Germany.

Abstract

Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are associated with diverse and severe human diseases and are also used by human pathogenic microbes for complement evasion. Therefore, dissecting the exact functions of the individual CFHR proteins will provide insights into the pathophysiology of such inflammatory and infectious diseases and will define the therapeutic potential of these proteins.

PMID:: 18602340; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Complement Factor H

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci. [Vaccine. 2008]
Review The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci.
Zipfel PF, Hallström T, Hammerschmidt S, Skerka C. Vaccine. 2008 Dec 30; 26 Suppl 8:I67-74.
Review Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H. [Clin Exp Immunol. 2008]
Review Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.
de Córdoba SR, de Jorge EG. Clin Exp Immunol. 2008 Jan; 151(1):1-13.
Review Complement factor H related proteins in immune diseases. [Vaccine. 2008]
Review Complement factor H related proteins in immune diseases.
Skerka C, Zipfel PF. Vaccine. 2008 Dec 30; 26 Suppl 8:I9-14.
Review [The role of complement in physiology and pathology]. [Postepy Hig Med Dosw (Online)....]
Review [The role of complement in physiology and pathology].
Klaska I, Nowak JZ. Postepy Hig Med Dosw (Online). 2007; 61:167-77.
Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome. [Blood. 2009]
Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome.
Abarrategui-Garrido C, Martínez-Barricarte R, López-Trascasa M, de Córdoba SR, Sánchez-Corral P. Blood. 2009 Nov 5; 114(19):4261-71. Epub 2009 Sep 10.

See reviews... See all...

Cited by 17 PubMed Central articles

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. [Clin Dev Immunol. 2012]
Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi.
Hammerschmidt C, Hallström T, Skerka C, Wallich R, Stevenson B, Zipfel PF, Kraiczy P. Clin Dev Immunol. 2012; 2012:349657. Epub 2012 Jan 30.
Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration. [J Inflamm Res. 2008]
Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.
Qin S, Rodrigues GA. J Inflamm Res. 2008; 1:49-65. Epub 2008 Dec 2.
A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. [PLoS One. 2011]
A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.
Sivakumaran TA, Igo RP Jr, Kidd JM, Itsara A, Kopplin LJ, Chen W, Hagstrom SA, Peachey NS, Francis PJ, Klein ML, et al. PLoS One. 2011; 6(10):e25598. Epub 2011 Oct 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Factor H family proteins and human diseases.
Factor H family proteins and human diseases.
Trends Immunol. 2008 Aug ;29(8):380-7. Epub 2008 Jul 2 .

PubMed
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Bioorg Med Chem Lett. 2008 Aug 1 ;18(15):4433-7. Epub 2008 Jun 12 .

PubMed
Clinical utility of the PCA3 urine assay in European men scheduled for repeat bi...
Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy.
Eur Urol. 2008 Nov ;54(5):1081-8. Epub 2008 Jun 26 .

PubMed
Genetic contributions to the autoantibody profile in a rabbit model of Systemic ...
Genetic contributions to the autoantibody profile in a rabbit model of Systemic Lupus Erythematosus (SLE).
Vet Immunol Immunopathol. 2008 Oct 15 ;125(3-4):251-67. Epub 2008 Jul 3 .

PubMed
Clinical events in prostate cancer lifestyle trial: results from two years of fo...
Clinical events in prostate cancer lifestyle trial: results from two years of follow-up.
Urology. 2008 Dec ;72(6):1319-23. Epub 2008 Jul 7 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: