Abstract
To explore the therapeutic potential of imidazoline I(1) receptor ligands in motor dysfunction related to the basal ganglia, rigidity was induced in mice by intraperitoneal administration of reserpine. The imidazoline I(1) receptor agonists moxonidine and tizanidine reduced rigidity in a dose-dependent manner. Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity.
MeSH terms
-
Adrenergic alpha-Agonists / pharmacology
-
Adrenergic alpha-Antagonists / pharmacology
-
Animals
-
Antiparkinson Agents / pharmacology*
-
Benzazepines / pharmacology
-
Benzofurans / pharmacology
-
Clonidine / analogs & derivatives
-
Clonidine / pharmacology
-
Disease Models, Animal
-
Dose-Response Relationship, Drug
-
Electromyography
-
Idazoxan / pharmacology
-
Imidazoles / pharmacology
-
Imidazoline Receptors / agonists*
-
Imidazoline Receptors / metabolism
-
Injections, Intraperitoneal
-
Ligands
-
Male
-
Mice
-
Muscle Rigidity / chemically induced
-
Muscle Rigidity / drug therapy*
-
Muscle Rigidity / metabolism
-
Muscle Rigidity / physiopathology
-
Muscle, Skeletal / drug effects*
-
Muscle, Skeletal / metabolism
-
Muscle, Skeletal / physiopathology
-
Parkinsonian Disorders / chemically induced
-
Parkinsonian Disorders / drug therapy*
-
Parkinsonian Disorders / metabolism
-
Parkinsonian Disorders / physiopathology
-
Reserpine / administration & dosage
-
Time Factors
-
Yohimbine / pharmacology
Substances
-
Adrenergic alpha-Agonists
-
Adrenergic alpha-Antagonists
-
Antiparkinson Agents
-
Benzazepines
-
Benzofurans
-
Imidazoles
-
Imidazoline Receptors
-
Ligands
-
imidazoline I1 receptors
-
Yohimbine
-
tizanidine
-
Reserpine
-
moxonidine
-
efaroxan
-
Clonidine
-
Idazoxan
-
benalfocin