Neurosci Biobehav Rev. 2008 Oct;32(8):1533-43. Epub 2008 Jun 17.

The cyclic AMP phenotype of fragile X and autism.

Kelley DJ, Bhattacharyya A, Lahvis GP, Yin JC, Malter J, Davidson RJ.

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Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin, Madison, WI, USA. djkelley@wisc.edu

Abstract

Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.

PMID:: 18601949; [PubMed - indexed for MEDLINE]
PMCID:: PMC2642647

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