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    Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):704-11.

    Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9).

    Huang M, Mitchell BS.

    Source

    Department of Medicine, Division of Oncology, Stanford Cancer Center, Stanford University, Stanford, California 94305-5796, USA.

    Abstract

    DHX-9, a member of the DEXH family of RNA helicases, unwinds dsRNA/dsDNA by ATP or GTP-dependent hydrolysis. We asked whether DHX-9 played a role in the GTP depletion-induced inhibition of rRNA synthesis and/or nucleolar disruption. MPA, a specific inhibitor of inosine monophosphate dehydrogenase (IMPDH), induced a rapid translocation of DHX-9 from the nucleolus to the nucleus. EGFP-tagged DHX-9 mutated at the GTP binding site also localized to the nucleus. However, knockdown of DHX-9 by siRNA did not inhibit the rRNA synthesis or cause the nucleolar disruption. Thus, DHX-9 translocation found with IMPDH inhibition does not mediate the inhibition of rRNA synthesis.

    PMID:
    18600529
    [PubMed - indexed for MEDLINE]

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