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    Cancer Cell. 2008 Jul 8;14(1):10-21.

    The HECT family of E3 ubiquitin ligases: multiple players in cancer development.

    Bernassola F, Karin M, Ciechanover A, Melino G.

    Source

    Department of Experimental Medicine and Biochemical Sciences, Biochemistry IDI-IRCCS Laboratory, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

    Abstract

    The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.

    PMID:
    18598940
    [PubMed - indexed for MEDLINE]

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