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Genome Biol. 2008;9(6):225. doi: 10.1186/gb-2008-9-6-225. Epub 2008 Jun 24.

What makes pathogens pathogenic.

Author information

  • 1Center for Genomic Sciences, Allegheny General Hospital, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA. gehrlich@wpahs.org

Abstract

Metazoans contain multiple complex microbial ecosystems in which the balance between host and microbe can be tipped from commensalism to pathogenicity. This transition is likely to depend both on the prevailing environmental conditions and on specific gene-gene interactions placed within the context of the entire ecosystem.

PMID:
18598378
[PubMed - indexed for MEDLINE]
PMCID:
PMC2481411
Free PMC Article

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