Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2008 Jul 2;3(7):e2553. doi: 10.1371/journal.pone.0002553.

Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.

Author information

  • 1Department of Pathology, University of Washington, Seattle, Washington, United States of America. jun.xu@tufts.edu

Abstract

Jarid1c, an X-linked gene coding for a histone demethylase, plays an important role in brain development and function. Notably, JARID1C mutations cause mental retardation and increased aggression in humans. These phenotypes are consistent with the expression patterns we have identified in mouse brain where Jarid1c mRNA was detected in hippocampus, hypothalamus, and cerebellum. Jarid1c expression and associated active histone marks at its 5'end are high in P19 neurons, indicating that JARID1C demethylase plays an important role in differentiated neuronal cells. We found that XX mice expressed Jarid1c more highly than XY mice, independent of their gonadal types (testes versus ovaries). This increased expression in XX mice is consistent with Jarid1c escape from X inactivation and is not compensated by expression from the Y-linked paralogue Jarid1d, which is expressed at a very low level compared to the X paralogue in P19 cells. Our observations suggest that sex-specific expression of Jarid1c may contribute to sex differences in brain function.

PMID:
18596936
[PubMed - indexed for MEDLINE]
PMCID:
PMC2438472
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk