(A) Amyloid deposition in dark grey, with lighter areas within the dark grey representing progressively more significant changes, as imaged with 11C Pittsburgh Compound-B, displayed in standard space lateral view. Reprinted from Buckner et al [35] with permission. Copyright 2005 by the Society for Neuroscience. (B) Late-myelinating regions in white; lateral brain view corresponds to positron emission tomography (PET)–derived image on the left. Reprinted from Meyer [37] with permission. (C) Amyloid deposition in dark grey, with lighter areas within the dark grey representing progressively more significant changes, as imaged with 11C Pittsburgh Compound-B, displayed in standard space medial view. Reprinted from Buckner et al [35] with permission. Copyright 2005 by the Society for Neuroscience. (D) Late-myelinating regions in white; medial brain view corresponds to PET-derived image on the left. Note: This image is “tilted” to expose the underside of the frontal and temporal lobe regions, which is not the case for the PET image on the left (C), and the exposed underside of those lobes should be ignored when comparing (C) and (D). Reprinted from Meyer [37] with permission.