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    Neuroreport. 2008 Jul 16;19(11):1107-10.

    MAO A VNTR polymorphism and variation in human morphology: a VBM study.

    Cerasa A, Gioia MC, Labate A, Lanza P, Magariello A, Muglia M, Quattrone A.

    Source

    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy. a.cerasa@isn.cnr.it

    Abstract

    The X-linked monoamine oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin catabolism, presents a well-characterized functional polymorphism (long and short variants) in the promoter region that alters the transcriptional activity of the gene and hence the function of the corresponding proteins. Using optimized voxel-based morphometry, we studied the effect of this functional polymorphism on brain morphology in normal individuals. Fifty-nine male healthy individuals (33 MAO A-high and 26 MAO A-low) were investigated. Voxel-based morphometry showed that the carriers of the long variant were significantly associated with loss of grey matter in orbitofrontal cortex, bilaterally. This study reveals pronounced genotype-related structural changes in a specific prefrontal region previously observed to mediate neurofunctional responses in behavioral tasks.

    PMID:
    18596609
    [PubMed - indexed for MEDLINE]

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