Ca2+-calmodulin-dependent protein kinase phosphorylation of ryanodine receptor may contribute to the beta-adrenergic regulation of myocardial contractility independently of increases in heart rate

Circ Res. 2008 Jul 3;103(1):e10-1; author reply e12. doi: 10.1161/CIRCRESAHA.108.178673.
No abstract available

Publication types

  • Comment
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Cyclic AMP-Dependent Protein Kinases / genetics
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Electrophysiologic Techniques, Cardiac
  • Isoproterenol / pharmacology
  • Mice
  • Myocardial Contraction / physiology*
  • Myocardium / enzymology*
  • Phosphorylation
  • Ryanodine Receptor Calcium Release Channel / genetics
  • Ryanodine Receptor Calcium Release Channel / metabolism*
  • Serine / metabolism
  • Sympathetic Nervous System / metabolism

Substances

  • Ryanodine Receptor Calcium Release Channel
  • Serine
  • Cyclic AMP-Dependent Protein Kinases
  • Isoproterenol