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1: Dig Dis Sci. 2009 Mar;54(3):522-9. Epub 2008 Jul 3.Click here to read Links

Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ileal J pouch-anal anastomosis.

Atila K, Terzi C, Canda AE, Akhisaroglu ST, Avci HS, Sarioglu S, Oktay G, Gulay Z.

Department of Surgery, School of Medicine, Dokuz Eylul University, Izmir, 35340, Turkey. koray.atila@deu.edu.tr

We aimed to evaluate the efficacy of treatment with partially hydrolyzed guar gum (PHGG) using a rat model of ileal pouch-anal anastomosis and pouchitis. In the J pouch groups, tissue myeloperoxidase activities were significantly higher than native myeloperoxidase activities (P = 0.020; P = 0.015; P = 0.004, respectively). A statistically significant difference in total histological score was detected in the J pouch + 5% dextran sulfate sodium (DSS) group, compared to the J pouch control and the J pouch + 5% DSS + PHGG groups (P < 0.01 and P < 0.01, respectively). There was a significant overgrowth of aerobes and anaerobes in the J pouch + 5% DSS group. This study demonstrated that rectal administration of PHGG attenuates the severity of pouchitis in a rat model. In conclusion, PHGG may be an additional therapeutic strategy for the treatment of pouchitis.

PMID: 18594969 [PubMed - indexed for MEDLINE]