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Genes Dev. 2008 Jul 1;22(13):1724-30. doi: 10.1101/gad.1691408.

DLC1: a significant GAP in the cancer genome.

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  • 1Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Abstract

Rho GTPases are believed to make important contributions to the development and progression of human cancer, but direct evidence in the form of somatic mutations analogous to those affecting Ras has been lacking. A recent study in Genes & Development by Xue and colleagues (1439-1444) now provides in vivo evidence that DLC1, a negative regulator of Rho, is a tumor suppressor gene deleted almost as frequently as p53 in common cancers such as breast, colon, and lung.

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PMID:
18593873
[PubMed - indexed for MEDLINE]
PMCID:
PMC2732422
Free PMC Article

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