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1: Genes Dev. 2008 Jul 1;22(13):1719-23.Click here to read Links
Comment on:
Genes Dev. 2008 Jun 15;22(12):1597-606.

Signaling silence--breaking ground and spreading out.

Woo HR, Richards EJ.

Department of Biology, Washington University in St. Louis, St. Louis, Missouri 63130, USA.

Among the persistent mysteries in epigenetics are the criteria by which specific regions of the genome are chosen for deposition of distinguishing chromatin marks. Once a particular region is modified, will the newly acquired epigenetic state spill onto neighboring regions of the genome or be confined to tidy patches? The report by Henderson and Jacobsen in the the previous issue of Genes & Development (1597-1606) addresses these questions while providing insight into the utility of DNA methylation for a eukaryotic genome.

PMID: 18593872 [PubMed - indexed for MEDLINE]