Cell Stem Cell. 2008 Jul 3;3(1):5-6.

Base behavior behind budding breasts: integrins and mammary stem cell activity.

Source

McArdle Lab for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison WI 53706, USA. alexander@oncology.wisc.edu

Abstract

In a recent Nature Cell Biology paper, Taddei et al. (2008) reveal that deletion of beta1 integrin from K5-expressing mammary epithelial basal cells specifically attenuates ductal stem cell activity, without dramatically altering the basal cell layer, or morphogenesis overall.

PMID:: 18593551; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. [Nat Cell Biol. 2008]
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.
Taddei I, Deugnier MA, Faraldo MM, Petit V, Bouvard D, Medina D, Fässler R, Thiery JP, Glukhova MA. Nat Cell Biol. 2008 Jun; 10(6):716-22. Epub 2008 May 11.
Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse. [Dev Biol. 1999]
Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse.
Klinowska TC, Soriano JV, Edwards GM, Oliver JM, Valentijn AJ, Montesano R, Streuli CH. Dev Biol. 1999 Nov 1; 215(1):13-32.
Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. [EMBO J. 2005]
Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli.
Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH, Hynes NE. EMBO J. 2005 Jun 1; 24(11):1942-53. Epub 2005 May 12.
Review Prospective isolation and functional analysis of stem and differentiated cells from the mouse mammary gland. [Stem Cell Rev. 2007]
Review Prospective isolation and functional analysis of stem and differentiated cells from the mouse mammary gland.
Regan J, Smalley M. Stem Cell Rev. 2007 Jun; 3(2):124-36.
Review [Mammary gland development: Role of basal myoepithelial cells]. [J Soc Biol. 2006]
Review [Mammary gland development: Role of basal myoepithelial cells].
Faraldo MM, Taddei-De La Hosseraye I, Teulière J, Deugnier MA, Moumen M, Thiery JP, Glukhova MA. J Soc Biol. 2006; 200(2):193-8.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Base behavior behind budding breasts: integrins and mammary stem cell activity.
Base behavior behind budding breasts: integrins and mammary stem cell activity.
Cell Stem Cell. 2008 Jul 3 ;3(1):5-6.

PubMed
Trypanosoma cruzi (Chagas' disease agent) reduces HIV-1 replication in human pla...
Trypanosoma cruzi (Chagas' disease agent) reduces HIV-1 replication in human placenta.
Retrovirology. 2008 Jul 1 ;5:53.

PubMed
Characterization of the DNA-binding motif of the arsenic-responsive transcriptio...
Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.
Biochem J. 2008 Nov 1 ;415(3):467-75.

PubMed
[1-(Phenylseleno)alkyl]stannanes-mixed selenium/tin analogs of acetals: preparat...
[1-(Phenylseleno)alkyl]stannanes-mixed selenium/tin analogs of acetals: preparation from alpha-hydroxystannanes and use for generating selenium-stabilized carbanions.
J Org Chem. 2008 Aug 1 ;73(15):6018-21. Epub 2008 Jul 2 .

PubMed
Bechet's colitis: a differential diagnosis in inflammations of the large intesti...
Bechet's colitis: a differential diagnosis in inflammations of the large intestine.
Aust N Z J Surg. 1991 Jul ;61(7):547-50.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: