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Methods Mol Biol. 2008;484:305-17. doi: 10.1007/978-1-59745-398-1_20.

Searching the protein interaction space through the MINT database.

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  • 1Department of Biology, University of Rome "Tor Vergata", Rome, Italy.


Many fundamental processes involve protein-protein interactions. Recent advances in technology make it possible to perform large-scale, genome-wide interaction mapping experiments that result in an always increasing amount of data. Protein-protein interaction databases are thus becoming a major resource for investigating biological networks and pathways. In this chapter we describe the Molecular INTeraction database (MINT). The MINT database aims at storing, in a structured format, information about protein-protein interactions (PPIs) by extracting experimental details from work published in peer-reviewed journals.

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