Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Alzheimers Dement. 2007 Jul;3(3):192-9. doi: 10.1016/j.jalz.2007.04.377.

Job demands and dementia risk among male twin pairs.

Author information

  • 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. guy.potter@duke.edu

Abstract

BACKGROUND:

Job characteristics may influence dementia risk, but some types of job complexity remain to be examined. Twin studies provide a useful methodology to examine job differences between pairs who share many environmental and genetic influences.

METHODS:

Members of the NAS-NRC Twins Registry of World War II Veterans received a clinical evaluation for dementia and had job ratings from the Dictionary of Occupational Titles.

RESULTS:

Cotwin-control models (n = 220 pairs) indicated lower dementia risk with greater job demands of reasoning, mathematics, language, and vocational training, with comparable results in case-control models (n=425 cases). These effects were significant among twin pairs discordant for 6 or more years, but not among those discordant between 3-5 years. Results were similar for Alzheimer's disease, and main effects were not further explained by zygosity or apolipoprotein E genotype.

CONCLUSIONS:

Jobs that utilize data, academic skills, and extensive vocational training may protect against dementia; however, in twin pairs these effects only emerged among individuals who remained free of dementia several years after onset in their sibling.

KEYWORDS:

Alzheimer’s disease; Dementia; Job complexity; Occupation; Twins

PMID:
18591984
[PubMed]
PMCID:
PMC2031862
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk