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Nat Cell Biol. 2008 Jul;10(7):757-9. doi: 10.1038/ncb0708-757.

Breaking down EMT.

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  • 1IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France.


Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important.

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