The double life of Irs

Cell Metab. 2008 Jul;8(1):7-9. doi: 10.1016/j.cmet.2008.06.010.

Abstract

The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action.

Publication types

  • Review
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology*
  • Animals
  • Fasting
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors / physiology
  • Glucose / metabolism
  • Insulin Receptor Substrate Proteins
  • Insulin Resistance
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Lipid Metabolism
  • Liver / metabolism
  • Mice
  • Phosphoproteins / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Foxo1 protein, mouse
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins
  • Irs1 protein, mouse
  • Irs2 protein, mouse
  • Phosphoproteins
  • Glucose