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1: Cell Metab. 2008 Jul;8(1):4-5.Links
Comment on:
Cell Metab. 2008 Jul;8(1):38-48.

The ongoing saga of sirtuins and aging.

Kaeberlein M.

Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA. kaeber@u.washington.edu

Sirtuins are known to slow aging in simple eukaryotes; however, viewing mammalian sirtuins as antiaging proteins may be overly simplistic. In this issue of Cell Metabolism, Li et al. (2008) provide evidence that SirT1 has properties consistent with both pro- and antiaging functions in mice.

PMID: 18590685 [PubMed - indexed for MEDLINE]