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Genome Biol. 2008;9(6):R104. doi: 10.1186/gb-2008-9-6-r104. Epub 2008 Jun 30.

Assignment of isochores for all completely sequenced vertebrate genomes using a consensus.

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  • 1Department of Genome-Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, D-85350 Freising, Germany.


We show that although the currently available isochore mapping methods agree on the isochore classification of about two-thirds of the human DNA, they produce significantly different results with regard to the location of isochore boundaries and isochore length distribution. We present a new consensus isochore assignment method based on majority voting and provide IsoBase, a comprehensive on-line database of isochore maps for all completely sequenced vertebrate genomes.

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