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Transplant Proc. 2008 Jun;40(5):1362-5. doi: 10.1016/j.transproceed.2008.02.083.

Treatment adherence in renal transplant recipients: a questionnaire survey on immunosuppressants.

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  • 1Department of Specific Organ Regulation (Urology), Osaka University, Graduate School of Medicine, Osaka, Japan.



To achieve a high graft survival rate, patient adherence to immunosuppressive therapy is critical. It is extremely difficult to establish the actual adherence status of transplant recipients; only a few surveys on the issue have been performed in Japan.


We conducted a questionnaire survey mainly on treatment adherence to calcineurin inhibitors among renal transplant recipients.


The survey demonstrated some degree of nonadherence in a relatively high percentage of the patients. The adherence rate was significantly lower for the evening than the morning dose (McNemar test, P < .001). It significantly decreased with time following transplantation for both the morning and the evening doses (logistic regression analysis, P = .025 and <.001, respectively).


Immunosuppressive treatment places a substantial burden on patients, some of whom cannot continue regular treatment at specified time points due to daily life restrictions after they have returned to work.

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