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Arch Iran Med. 2008 Jul;11(4):377-81. doi: 08114/AIM.007.

Effects of age and renal function on vitamin D status in men.

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  • 1Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

BACKGROUND:

In general, no study has examined the relationship between vitamin D status and key parameters of bone mineral homeostasis in healthy men in Iran. The effects of age and renal function on vitamin D status were determined in a cross-sectional study on a healthy population of Iranian men.

METHODS:

From January through February 2001, 520 men, aged 20 - 74 years were selected through a cluster randomized sampling from Shiraz. Serum 25-hydroxyvitamin D, intact parathyroid hormone, calcium, phosphorus, alkaline phosphatase, creatinine, and albumin were measured. Pearson and partial correlation coefficients were used to determine the association between variables.

RESULTS:

Five hundred twenty men with a mean+/-SD age of 45+/-15 years and a mean+/-SD 25-hydroxyvitamin D level of 35+/-17 nmol/L were enrolled into the study. Over 33.9% of men in Shiraz had a low level of 25-hydroxyvitamin D (<or=25 nmol/L). Serum 25-hydroxyvitamin D did not decline with age in men. Serum parathyroid hormone increased significantly by age in men, but it did not correlate with the decline in creatinine clearance. Men had a decline in serum phosphorus (r=0.23, P<0.0001) and calcium (r=0.14, P=0.001) concentrations by age. Creatinine clearance declined with age.

CONCLUSION:

In healthy men, the serum level of 25-hydroxyvitamin D did not decline with age. Nonetheless, the prevalence of vitamin D deficiency is high which warrants consideration of dietary vitamin D supplement in men.

PMID:
18588368
[PubMed - indexed for MEDLINE]
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