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Mol Cell Biochem. 2008 Sep;316(1-2):107-13. doi: 10.1007/s11010-008-9845-y. Epub 2008 Jun 28.

Protein kinase CK2 and cell polarity.

Author information

  • 1CEA, DSV, iRTSV, Laboratoire Transduction du signal, 17, rue des Martyrs, Grenoble, 38054, France.

Abstract

There is increasing evidence that protein kinase CK2 is involved, among a wide variety of cellular processes, in the maintenance of mammalian cell morphology and cell polarity. Here, we show that in epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions. In addition, inhibition of CK2 activity in mammary epithelial cells (MCF10A), using either the specific CK2 inhibitor TBB or siRNA-mediated CK2beta knockdown, induced differential phenotypes revealing an important role of this enzyme in epithelial cell morphology.

PMID:
18587631
[PubMed - indexed for MEDLINE]
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