Cell. 2008 Jun 27;133(7):1135-7.

Forging new ties between E. coli genes.

Source

Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA. grey@bioeng.ucsd.edu

Abstract

A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some cases the new connections enhance fitness. These findings reveal insights into the robustness and evolvability of gene networks.

PMID:: 18585345; [PubMed - indexed for MEDLINE]
PMCID:: PMC2806683

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Evolvability and hierarchy in rewired bacterial gene networks. [Nature. 2008]
Evolvability and hierarchy in rewired bacterial gene networks.
Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L. Nature. 2008 Apr 17; 452(7189):840-5.
Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations. [BMC Syst Biol. 2009]
Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations.
Zare H, Sangurdekar D, Srivastava P, Kaveh M, Khodursky A. BMC Syst Biol. 2009 Apr 14; 3:39. Epub 2009 Apr 14.
Regulation of P-fimbrial phase variation frequencies in Escherichia coli CFT073. [Infect Immun. 2007]
Regulation of P-fimbrial phase variation frequencies in Escherichia coli CFT073.
Holden N, Totsika M, Dixon L, Catherwood K, Gally DL. Infect Immun. 2007 Jul; 75(7):3325-34. Epub 2007 Apr 23.
Review Global regulators of transcription in Escherichia coli: mechanisms of action and methods for study. [Adv Appl Microbiol. 2008]
Review Global regulators of transcription in Escherichia coli: mechanisms of action and methods for study.
Grainger DC, Busby SJ. Adv Appl Microbiol. 2008; 65:93-113.
Review New insights into the regulatory networks of paralogous genes in bacteria. [Microbiology. 2010]
Review New insights into the regulatory networks of paralogous genes in bacteria.
Martínez-Núñez MA, Pérez-Rueda E, Gutiérrez-Ríos RM, Merino E. Microbiology. 2010 Jan; 156(Pt 1):14-22. Epub 2009 Oct 22.

See reviews... See all...

Cited by 1 PubMed Central article

Protein evolution in yeast transcription factor subnetworks. [Nucleic Acids Res. 2010]
Protein evolution in yeast transcription factor subnetworks.
Wang Y, Franzosa EA, Zhang XS, Xia Y. Nucleic Acids Res. 2010 Oct; 38(18):5959-69. Epub 2010 May 13.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Forging new ties between E. coli genes.
Forging new ties between E. coli genes.
Cell. 2008 Jun 27 ;133(7):1135-7.

PubMed
The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in...
The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats.
J Bone Miner Res. 1991 Apr ;6(4):339-46.

PubMed
Development of a sensitive, rapid, biotin-streptavidin based chemiluminescent en...
Development of a sensitive, rapid, biotin-streptavidin based chemiluminescent enzyme immunoassay for human thyroid stimulating hormone.
Talanta. 2008 May 30 ;75(4):965-72. Epub 2008 Jan 6 .

PubMed
Strengths and limitations of genetic mouse models of Parkinson's disease.
Strengths and limitations of genetic mouse models of Parkinson's disease.
Parkinsonism Relat Disord. 2008 ;14 Suppl 2:S84-7. Epub 2008 Jun 27 .

PubMed
Impact of the use of propofol remifentanil goal-directed sedation adapted by nur...
Impact of the use of propofol remifentanil goal-directed sedation adapted by nurses on the time to extubation in mechanically ventilated ICU patients: the experience of a French ICU.
Ann Fr Anesth Reanim. 2008 Jun ;27(6):481.e1-8. Epub 2008 Jun 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: