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    Cancer Invest. 2008 Jul;26(6):638-41.

    Soft tissue sarcoma in the setting of chronic cutaneous graft versus host disease after allogenic bone marrow transplantation.

    Bylund KC, Giampoli E, Singh D, Doerr T, Sahasrabudhe D, Liesveld J, Constine LS.

    Source

    University of Rochester School of Medicine, Rochester, New York 14642, USA. kevin bylund@urmc.rochester.edu

    Abstract

    Second primary cancers are approximately 2.1-2.8 times more common in survivors of bone marrow transplant than in the age-matched general population. We describe a patient who developed high-grade sarcoma in two disparate sites that were clinically involved by chronic cutaneous graft versus host disease (GVHD). This occurred 3.5 years after bone marrow transplant for acute myelogenous leukemia (AML). This suggests that malignant sarcomas may develop in the setting of chronic GVHD, and close surveillance of GVHD-related nodules is warranted.

    PMID:
    18584356
    [PubMed - indexed for MEDLINE]

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