The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction

Anaesthesia. 2008 Jul;63(7):701-4. doi: 10.1111/j.1365-2044.2007.05408.x.

Abstract

The usefulness of mannitol in the priming fluid for cardiopulmonary bypass is uncertain in patients with normal renal function, and has not been studied in patients with established renal dysfunction. We studied 50 patients with serum creatinine between 130 and 250 micromol.l(-1) having cardiac surgery. Patients were randomised to receive mannitol 0.5 g.kg(-1), or an equivalent volume of Hartmann's solution, in the bypass prime. There were no differences between the groups in plasma creatinine or change in creatinine from baseline, urine output, or fluid balance over the first three postoperative days. We conclude that mannitol has no effect on routine measures of renal function during cardiac surgery in patients with established renal dysfunction.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / prevention & control
  • Aged
  • Aged, 80 and over
  • Cardiopulmonary Bypass / adverse effects
  • Cardiopulmonary Bypass / methods*
  • Creatinine / blood
  • Diuretics, Osmotic / therapeutic use*
  • Female
  • Humans
  • Kidney / drug effects*
  • Kidney / physiopathology
  • Male
  • Mannitol / therapeutic use*
  • Middle Aged
  • Prospective Studies

Substances

  • Diuretics, Osmotic
  • Mannitol
  • Creatinine