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Genes Dev. 2008 Jul 15;22(14):1962-71. doi: 10.1101/gad.1664408. Epub 2008 Jun 25.

TEAD mediates YAP-dependent gene induction and growth control.

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  • 1Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA.

Abstract

The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

PMID:
18579750
[PubMed - indexed for MEDLINE]
PMCID:
PMC2492741
Free PMC Article
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