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Fertil Steril. 2009 Jun;91(6):2391-8. doi: 10.1016/j.fertnstert.2008.04.014. Epub 2008 Jun 24.

Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes.

Author information

  • 1McGill Reproductive Center, McGill University Health Centre, Montreal, Quebec, Canada.

Abstract

OBJECTIVE:

To evaluate obstetric outcomes with oocyte vitrification after ovarian stimulation (OS) and in vitro maturation (IVM) of immature oocytes.

DESIGN:

A prospective trial from October 2003 to April 2007.

SETTING:

University-based medical center.

PATIENT(S):

OS group: 38 patients undergoing intrauterine insemination who overresponded to OS. IVM group: 20 patients who had previous unsuccessful intrauterine insemination.

INTERVENTION(S):

Mature oocyte retrieval following OS. Immature oocyte retrieval and IVM. Oocyte vitrification, thawing, insemination, and transfer of the resulting embryos.

MAIN OUTCOME MEASURE(S):

Live-birth rates and obstetric outcomes.

RESULT(S):

The OS group was superior to the IVM group in terms of oocyte survival (81.4 +/- 22.6% vs. 67.5 +/- 26.1%), fertilization rate (75.6 +/- 22.5% vs. 64.2 +/- 19.9%), and cumulative embryo score (38.4 +/- 22.3 vs. 20.0 +/- 13.8). However, the differences in the implantation rate per embryo (19.1 +/- 25.8% vs. 9.6 +/- 24.1%), clinical pregnancy rate per cycle started (44.7%, vs. 20.0%), and live-birth rate per cycle started (39.5% vs. 20.0%) were not statistically significant. Twenty healthy babies were born in the OS group and four in the IVM group.

CONCLUSION(S):

Pregnancies achieved with vitrification of oocytes after OS and IVM treatments do not appear to be associated with adverse pregnancy outcomes. Vitrification of IVM oocytes represents a novel option for fertility preservation.

PMID:
18579139
[PubMed - indexed for MEDLINE]
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