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Exp Gerontol. 2008 Sep;43(9):867-70. doi: 10.1016/j.exger.2008.05.012. Epub 2008 Jun 5.

Increase of Dkk-3 blood plasma levels in the elderly.

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  • 1Endocrinology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, Innsbruck A-6020, Austria.


Gene expression of the secreted glycoprotein Dkk-3 is upregulated during cellular senescence in prostate basal epithelial cells and altered in age-related disorders of the human prostate. In order to quantify the influence of such age- and disease-related changes of Dkk-3 levels in body fluids, we established a highly specific and sensitive indirect IEMA. Results revealed a significant increase of Dkk-3 blood plasma levels in the elderly (1.17+/-0.36 vs. 1.61+/-0.61 nmol/L) indicating a non-negligible physiological role and its use as a marker for senescence not only in vitro but also in vivo.

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