Format

Send to:

Choose Destination
See comment in PubMed Commons below
Brain Behav Immun. 2008 Nov;22(8):1173-7. doi: 10.1016/j.bbi.2008.05.003. Epub 2008 Jun 20.

Pneumonia as a long-term consequence of chronic psychological stress in BALB/c mice.

Author information

  • 1Department of Immunology, Ernst-Moritz-Arndt-University Greifswald, Sauerbruchstrasse, D-17487 Greifswald, Germany. cornelia.kiank@uni-greifswald.de

Abstract

Recently, we have shown that female BALB/c mice are highly sensitive to chronic psychological stress. They develop systemic neuroendocrine disturbances, a hypermetabolic syndrome, behavioral alterations and severe immunosuppression with a reduced antibacterial response during experimental infection. Here, we show that chronically stressed mice spontaneously suffered from increased bacterial load in the liver and lung that sustained for up to 10 days after the termination of stress exposure. Immediately after the last chronic stress cycle, splenocytes had a reduced ability to produce IFNgamma after ex vivo stimulation with LPS while showing enhanced inducibility of IL-10. When healthy animals were treated with anti-IFNgamma antiserum the antibacterial response against the small numbers of endogenous bacteria that physiologically penetrate the intestinal barrier was reduced causing increased bacterial burden in the liver. Thus, a deficient antibacterial response to translocated commensals in chronically stressed animals can contribute to long-lasting pneumonia.

PMID:
18571893
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk