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J Am Acad Dermatol. 2008 Jul;59(1):91-8. doi: 10.1016/j.jaad.2008.03.007.

A histologic review of 27 patients with lichen planopilaris.

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  • 1Faculty of Medicine, North Eastern Ohio Universities College of Medicine, Rootstown, Ohio, USA.

Abstract

BACKGROUND:

Lichen planopilaris (LPP) is a potential trichologic emergency that can result in permanent scarring alopecia. Histopathology is a key component of the diagnostic work-up.

OBJECTIVE:

To identify the key histologic features that characterize LPP in order to facilitate diagnosis, ultimately leading to improved patient outcomes.

METHODS:

Scalp biopsy specimens from 27 confirmed cases of LPP were reviewed in a blinded fashion to determine diagnostically helpful histologic features.

RESULTS:

Absence of arrector pili muscles and sebaceous glands, a perivascular and perifollicular lymphocytic infiltrate in the reticular dermis and mucinous perifollicular fibroplasia within the upper dermis with absence of interfollicular mucin, and superficial perifollicular wedge-shaped scarring were characterizing features.

LIMITATIONS:

Sample size was limited, given that biopsy specimens were taken from lesions at varying stages of evolution and findings vary with disease stage.

CONCLUSIONS:

This study confirms many previously reported histologic features and highlights new characterizing features of mucinous perifollicular fibroplasia.

PMID:
18571598
[PubMed - indexed for MEDLINE]
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