OBJECTIVE: To compare comorbid psychopathology and substance use among women with bulimia nervosa (BN) based on smoking status. METHOD: Forty women diagnosed with BN (20 smokers, 20 nonsmokers) completed written self-report measures of depressive symptoms, substance use, and alcohol abuse. RESULTS: Smokers reported more symptoms of depression and alcohol abuse and were more likely to use alcohol than nonsmokers, whereas caffeine consumption did not significantly differ between the two groups. CONCLUSION: Smokers with BN may represent a distinct subtype characterized by high rates of comorbid depression and alcohol abuse. (c) 2008 by Wiley Periodicals, Inc.