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Neurocase. 2008;14(2):162-8. doi: 10.1080/13554790802060839.

Progressive apraxia of speech presenting as isolated disorder of speech articulation and prosody: a case report.

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  • 1Unit of Neurology, Regina Apostolorum Hospital, Rome, Italy.


Apraxia of speech (AOS) is a rare disorder of motor speech programming, and few case reports have included sufficient description of both clinical findings and lesion localization. We report a case with an isolated progressive speech articulation deficit and brain involvement restricted to the left superior frontal gyrus. This case suggests that slowly progressive AOS may be a clinical disorder distinct from primary progressive aphasia, and that it can occur without language disorders or bucco-facial apraxia. Our findings highlight the importance of the left hemisphere in speech articulatory deficits and suggest that the left superior frontal gyrus plays a crucial role in specific articulatory processes.

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