Neurocase. 2008;14(2):125-30.

Behavioral symptoms after pallido-nigral lesions: a clinico-pathological case.

Adam J, Baulac M, Hauw JJ, Laplane D, Duyckaerts C.

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Raymond Escourolle Neuropathology Laboratory, Hopital de La Salpetriere, Inserm U679, APHP, Pierre et Marie Curie Paris VI University, Paris, France.

Abstract

A 59-year-old patient presented with compulsive behaviors and lasting apathy after carbon monoxide intoxication. The apathy could be overcome by external stimulation (self-activation deficit). There was severe neuronal loss bilaterally in the anterior part of the pallidum and in the substantia nigra, pars reticulata. This first clinico-pathological case of a self-activation deficit illustrates the dissociation between motor and behavioral symptoms in lesions of the pallido-nigral complex, with the behavioral symptoms being related to lesions of the substantia nigra, pars reticulata and of the anterior part of the pallidum.

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