J Reprod Med. 2008 May;53(5):360-2.

Recombinant factor VIIa to treat late radiation-induced hemorrhagic cystitis: a case report.

Source

Division of Gynecologic Oncology, St. Vincent Hospitals, Indianapolis, Indiana, USA. jgeisler@indianawomensoncology.com

Abstract

BACKGROUND:

Late radiation cystitis is one of the most difficult complications of radiation therapy for pelvic malignancies.

CASE:

A 29-year-old woman with a history of cervical cancer presented with radiation-induced hemorrhagic cystitis. The patient received multiple units of packed red blood cells while undergoing several intravesical treatments, including continuous bladder irrigation, 4% formalin, 0.15% AgNO3 and Mg(OH)2 with Al(OH)3. The bleeding finally was stopped by the use of intravenous recombinant factor VIIa.

CONCLUSION:

When hemorrhagic cystitis related to late radiation complications is refractory to conventional management, intravenous recombinant factor VIIa may be of benefit.

PMID:: 18567283; [PubMed - indexed for MEDLINE]

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