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Am J Obstet Gynecol. 2008 Aug;199(2):196.e1-7. doi: 10.1016/j.ajog.2008.04.028. Epub 2008 Jun 20.

Combined adverse effect of African American race and deep stromal invasion on survival following radical hysterectomy for cervical cancer.

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  • 1Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

OBJECTIVE:

The objective of the study was to explore the effect of African American race on survival following radical hysterectomy for cervical cancer.

STUDY DESIGN:

We reviewed all cases of stage IA-IIA cervical cancer treated with radical hysterectomy at our institution (1987-2001). Characteristics between races were compared using Mann Whitney U and chi(2) tests. Hazard ratios (HR) of survival were calculated using Cox regression.

RESULTS:

We identified 134 Caucasian and 66 African American patients. There was a trend toward worse survival among African Americans (81.8% vs 88.8%, P = .165). An interaction effect between race and depth of stromal invasion was observed (P = .005), and the combination of African American race and deep stromal invasion had a powerful, independent effect on survival (HR of death 7.04 [95% confidence interval 2.48 to 19.94]).

CONCLUSION:

The combination of African American race and deep stromal invasion has an adverse effect on survival following radical hysterectomy for cervical cancer and may warrant use of adjuvant therapy.

PMID:
18565488
[PubMed - indexed for MEDLINE]
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