J Psychopharmacol. 2009 Jun;23(4):468-71. Epub 2008 Jun 18.

Modafinil treatment of amphetamine abuse in adult ADHD.

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Counties Assertive Outreach, The Point, Granite Way, Mountsorrel, Leicestershire, UK.

Abstract

Substance abuse is a frequent co-morbid condition of adult attention deficit hyperactivity disorder (ADHD). Treatment with conventional psychostimulants in adult ADHD with co-morbid stimulant abuse may be problematic. In this study, we report the case of a patient with adult ADHD with co-morbid amphetamine abuse who was treated successfully with the non-stimulant alertness-promoting drug modafinil. The drug resolved both the inattention/hyperactivity symptoms as well as the amphetamine abuse. Modafinil may be a suitable candidate treatment for adults with ADHD and stimulant abuse.

PMID:: 18562425; [PubMed - indexed for MEDLINE]

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Review A qualitative review of issues arising in the use of psycho-stimulant medications in patients with ADHD and co-morbid substance use disorders. [Curr Med Res Opin. 2008]
Review A qualitative review of issues arising in the use of psycho-stimulant medications in patients with ADHD and co-morbid substance use disorders.
Kollins SH. Curr Med Res Opin. 2008 May; 24(5):1345-57. Epub 2008 Apr 1.
Review A review of the use of modafinil for attention-deficit hyperactivity disorder. [Expert Rev Neurother. 2006]
Review A review of the use of modafinil for attention-deficit hyperactivity disorder.
Turner D. Expert Rev Neurother. 2006 Apr; 6(4):455-68.
Review Substance abuse in patients with attention-deficit hyperactivity disorder : therapeutic implications. [CNS Drugs. 2005]
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Schubiner H. CNS Drugs. 2005; 19(8):643-55.
Review The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review. [J Clin Psychiatry. 1995]
Review The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review.
Schubiner H, Tzelepis A, Isaacson JH, Warbasse LH 3rd, Zacharek M, Musial J. J Clin Psychiatry. 1995 Apr; 56(4):146-50.
Review Use of modafinil for the treatment of attention deficit/hyperactivity disorder. [Ann Pharmacother. 2006]
Review Use of modafinil for the treatment of attention deficit/hyperactivity disorder.
Lindsay SE, Gudelsky GA, Heaton PC. Ann Pharmacother. 2006 Oct; 40(10):1829-33. Epub 2006 Sep 5.

See reviews... See all...

Cited by 1 PubMed Central article

Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. [Pharmacol Biochem Behav. 2010]
Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.
Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B. Pharmacol Biochem Behav. 2010 Jun; 95(4):449-56. Epub 2010 Mar 25.

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