Format

Send to:

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2008 Nov 3;193(1):63-8. doi: 10.1016/j.bbr.2008.04.020. Epub 2008 May 2.

A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia.

Author information

  • 1Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital (MGH), Harvard Medical School, MA 02129, USA. ddougherty@partners.org

Abstract

Functional neuroimaging studies suggest that a lateral network in the brain is associated with the sensory aspects of pain perception while a medial network is associated with affective aspects. The highest concentration of opioid receptors is in the medial network. There is significant evidence that endogenous opioids are central to the experience of pain and analgesia. We applied an integrative multimodal imaging approach during acupuncture. We found functional magnetic resonance imaging signal changes in the orbitofrontal cortex, insula, and pons and [11C]diprenorphine positron emission tomography signal changes in the orbitofrontal cortex, medial prefrontal cortex, insula, thalamus, and anterior cingulate cortex. These findings include brain regions within both the lateral and medial pain networks.

PMID:
18562019
[PubMed - indexed for MEDLINE]
PMCID:
PMC2538486
Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk