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Kidney Int. 2008 Jul;74(1):9-11. doi: 10.1038/ki.2008.127.

HOming in on arteriovenous fistula survival.

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  • 1Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri 65212, USA. durantew@health.missouri.edu

Abstract

Vascular access failure is a major clinical problem for patients on hemodialysis, but therapeutic approaches aimed at improving arteriovenous fistula (AVF) dysfunction remain elusive. Using a murine AVF model, Juncos et al. demonstrate for the first time that the stress protein heme oxygenase-1 (HO-1) is induced in AVFs and that HO-1 is a critical determinant of AVF survival.

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PMID:
18560362
[PubMed - indexed for MEDLINE]
PMCID:
PMC2645071
Free PMC Article

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