Antimicrob Agents Chemother. 2008 Aug;52(8):2937-9. Epub 2008 Jun 16.

Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia.

Mokrousov I, Otten T, Manicheva O, Potapova Y, Vishnevsky B, Narvskaya O, Rastogi N.

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Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia. igormokrousov@yahoo.com

Abstract

In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis.

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PMCID:: PMC2493099

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