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    Clin Infect Dis. 2008 Aug 1;47(3):421-4.

    Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy.

    Source

    Dept of Medicine, University of California, San Francisco, CA 94110, USA. chare@php.ucsf.edu

    Abstract

    Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and <or=50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.

    PMID:
    18558886
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2586907
    Free PMC Article

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